Frequent cosmetic use may disrupt skin microbiota balance by causing derma effects. At QACS, we assist manufacturers avoid cosmetic derived skin dysbiosis with Cosmetic Microbiome analysis services. We support the maintenance of the beneficial skin microflora by using microbiological/molecular methods and clinical trials for Microbiome Friendly and Microbiome Balance claim substantiation. Skin Microbiome studies are supported by years of clinical efficacy testing experience and molecular biology know-how. Studies, adopted to your product’s needs and budget, are provided in the form of customized protocols. QACS assists you to support product microbiome claims, choose one that suits you best!

Microbiome Friendly

Microbiome Friendly testing reveals information about the product’s effect on the skin microbiome and it is an in vitro study. Competent microbiome friendly in vitro studies are offered in rapid turnaround times to prove that the skin microbiome is not altered significantly by the product during use.

The product is challenged with a complete set of microbes, specific for the skin area in question (face, body, scalp, armpit, foot etc) including the usual pathogens of the area. Also, a solution comprising the total microflora of the specific skin region, swabbed from selected volunteers, is challenged against the formulated product. This gives information regarding product effect on microbial biodiversity of the area.

Microbiome Balance

If the goal of your product is to retain or restore the natural balance of the skin microbiome, a different approach is used including both in vivo and laboratory testing. As Microbiome Balance studies indicate the alterations cosmetics have on the skin microbiome, trials are more extensive in order to substantiate this specific claim.

A dedicated team can undertake

  • Trial design
  • Selection of suitable volunteers from QACS extensive database
  • Microbiological and physiological skin parameters during trial
  • Sampling and Microbiome samples analysis
  • Results interpretation & Claim substantiation report

Basic package: includes volunteers, microbiological and physiological analyses. The study reveals the effect of your product on the different groups of microbes (like Staphylococcus spp, TAMC and Propionibacterium spp, etc) of selected volunteers during the study period.

Standard package: Basic, but also including species identification in selected bacterial colonies.

Premium package: includes volunteers, microbiological and physiological analyses along with Next Generation Sequencing (NGS) analysis. This package is the most accurate to reveal the effect of your product on the entire skin microbiome during the study period.

Why conduct Cosmetic Microbiome Analysis?

Over the last years, the connection between skin microbiome and cosmetics use is under thorough study. The skin is colonized by myriads of different microorganisms, the majority of which are bacteria while fungi & viruses are also present in lower numbers. Those microorganisms represent the skin microbiome. They form an ecosystem and are usually harmless or may even be beneficial, as they cooperate with the immune system and compete against pathogenic microbes. The antimicrobial activity of cosmetic preservatives and long-term cosmetic usage may disrupt the normal skin microflora. This can lead to dysbiosis, the disruption in the balance of the skin microbiota with adverse effects on the skin such as new allergies, skin irritation, discoloration and others.

Related Testing

Challenge Testing is the tool to substantiate antimicrobial preservation efficacy against microbial contamination. Preservative Efficacy Testing (PET) also known as Challenge Testing is the appropriate tool to substantiate antimicrobial preservation efficacy against microbial contamination. At QACS, The Challenge Test Laboratory, we apply several challenge testing protocols.

Patch & HRIPT tests evaluate non-irritant and hypoallergenic claims. Potential irritants and product tolerability are assessed via Patch test & HRIPT (Human Repeated Insult Patch Tests). Dermatological compatibility tests from QACS follow the guidelines regarding the use of human volunteers in compatibility testing of finished cosmetic products. Our dermatological testing services assist you assess non-irritant and hypoallergenic cosmetic claims.